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Home - Products - TGF-beta/Smad - TGFBR - A 83-01

A 83-01

CAS No. 909910-43-6

A 83-01( A83-01 | A-83-01 )

Catalog No. M16535 CAS No. 909910-43-6

A potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    A 83-01
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively.
  • Description
    A potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively; dispalys weak or no inhibitory activity again transcriptional activity of ALK6 and ALK1/2/3; prevents phosphorylation of Smad2/3 and the growth inhibition induced by TGF-beta with no effects on BMP signaling, ERK and p38 MAPK.
  • In Vitro
    A 83-01 (GMP) induces human foreskin fibroblasts converts into ardiomyocyte-like cells a more open-chromatin conformation at key heart developmental genes.A 83-01 (GMP) induces cord blood or fetal liver-derived CD34+ cells converts into pluripotent cells.
  • In Vivo
    A 83-01 (GMP) (human foreskin fibroblast with aMHC-GFP; incubates in vitro 6 days than transplanted into the infarcted hearts of immunodeficient mice) induces fibroblasts converts into cardiomyocyte-like cells in infarcted mouse heart.
  • Synonyms
    A83-01 | A-83-01
  • Pathway
    TGF-beta/Smad
  • Target
    TGFBR
  • Recptor
    ALK4|ALK5|ALK7
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    909910-43-6
  • Formula Weight
    421.5168
  • Molecular Formula
    C25H19N5S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    S=C(N1N=C(C2=NC(C)=CC=C2)C(C3=CC=NC4=CC=CC=C34)=C1)NC5=CC=CC=C5
  • Chemical Name
    1H-Pyrazole-1-carbothioamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tojo M, et al. Cancer Sci. 2005 Nov;96(11):791-800. 2. Yuan X, et al. Stem Cells. 2011 Mar;29(3):549-53. 3. Yamamura S, et al. Int J Cancer. 2012 Jan 1;130(1):20-8. 4. Minowa T, et al. Br J Cancer. 2009 Dec 1;101(11):1884-90.
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