
A 83-01
CAS No. 909910-43-6
A 83-01( A83-01 | A-83-01 )
Catalog No. M16535 CAS No. 909910-43-6
A potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 48 | In Stock |
![]() ![]() |
10MG | 80 | In Stock |
![]() ![]() |
50MG | 242 | In Stock |
![]() ![]() |
100MG | Get Quote | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameA 83-01
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively.
-
DescriptionA potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively; dispalys weak or no inhibitory activity again transcriptional activity of ALK6 and ALK1/2/3; prevents phosphorylation of Smad2/3 and the growth inhibition induced by TGF-beta with no effects on BMP signaling, ERK and p38 MAPK.
-
In VitroA 83-01 (GMP) induces human foreskin fibroblasts converts into ardiomyocyte-like cells a more open-chromatin conformation at key heart developmental genes.A 83-01 (GMP) induces cord blood or fetal liver-derived CD34+ cells converts into pluripotent cells.
-
In VivoA 83-01 (GMP) (human foreskin fibroblast with aMHC-GFP; incubates in vitro 6 days than transplanted into the infarcted hearts of immunodeficient mice) induces fibroblasts converts into cardiomyocyte-like cells in infarcted mouse heart.
-
SynonymsA83-01 | A-83-01
-
PathwayTGF-beta/Smad
-
TargetTGFBR
-
RecptorALK4|ALK5|ALK7
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number909910-43-6
-
Formula Weight421.5168
-
Molecular FormulaC25H19N5S
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESS=C(N1N=C(C2=NC(C)=CC=C2)C(C3=CC=NC4=CC=CC=C34)=C1)NC5=CC=CC=C5
-
Chemical Name1H-Pyrazole-1-carbothioamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Tojo M, et al. Cancer Sci. 2005 Nov;96(11):791-800.
2. Yuan X, et al. Stem Cells. 2011 Mar;29(3):549-53.
3. Yamamura S, et al. Int J Cancer. 2012 Jan 1;130(1):20-8.
4. Minowa T, et al. Br J Cancer. 2009 Dec 1;101(11):1884-90.
molnova catalog



related products
-
ITD-1
ITD-1 is a potent, selective TGF-β inhibitor that induces type II TGFβ receptor (TGFBR2) degradation with IC50 of 0.85 uM.
-
Kartogenin
Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
-
ALK5-IN-16i
A potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3.